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Tll you doctand phamacist i you a allgic tallopuinol any oth mdications. tll you doctand phamacist what psciption and nonpsciption mdications, vitamins, nutitional supplmnts, and hbal poducts you a taking. B su tmntion any th ollowing: amoxicillin (Amoxil, Timox); ampicillin (Polycillin, Pincipn); anticoagulants (‘blood thinns’) such as waain (Coumadin); canc chmothapy dugs such as cyclophosphamid (Cytoxan) and mcaptopuin (Puinthol); chlopopamid (Diabins); diutics (‘wat pills’); mdications that suppss th immun systm such as azathiopin (Imuan) and cyclospoin (Noal, Sandimmun); oth mdications gout such as pobncid (Bnmid) and sulinpyazon (Antuan); and tolbutamid (Oinas). You doctmay nd tchang th doss you mdications monityou caully sid cts. tll you docti you hav hav v had kidny liv disas hat ailu. tll you docti you a pgnant, plan tbcom pgnant, a bast-ding. I you bcom pgnant whil taking allopuinol, call you docto. you should know that allopuinol may mak you dowsy. Dnot div a ca opat machiny until you know how this mdication acts you. ask you doctabout th sa us alcoholic bvags whil you a taking allopuinol. Alcohol may dcas th ctivnss allopuinol.
Gout is a mtabolic disod which is chaactizd by hypuicmia and sultant dposition monosodium uat in th tissus, paticulaly th joints and kidnys. Th tiology this hypuicmia is th ovpoduction uic acid in lation tth patint’s ability txct it. I pogssiv dposition uats is tb astd vsd, it is ncssay tduc th sum uic acid lvl blow th satuation point tsuppss uat pcipitation.
Th managmnt patints with signs and symptoms pimay sconday gout (acut attacks, tophi, joint dstuction, uic acid lithiasis, and/nphopathy). th managmnt patints with lukmia, lymphoma and malignancis wha civing canc thapy which causs lvations sum and uinay uic acid lvls. Tatmnt with ZYLOPIM (allopuinol) should b discontinud whn th potntial ovpoduction uic acid is nlong psnt. th managmnt patints with cuntcalcium oxalat calculi whos daily uic acid xction xcds 800 mg/day in mal patints and 750 mg/day in mal patints. Thapy in such patints should b caully assssd initially and assssd piodically tdtmin in ach cas that tatmnt is bnicial and that th bnits outwigh th isks.
In th managmnt ovdosag th is nspciic antidot ZYLOPIM (allopuinol) . Th has bn nclinical xpinc in th managmnt a patint whhas takn massiv amounts ZYLOPIM (allopuinol) .
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