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Mebeverine violates the entrance of Naions into the cell by preventing the fast sodium channels myocyte cell membranealso it blocks the entering through the slow channels of ions Ca2hinders the process of depolarization of the cell membrane and prevents the reduction of muscle fibersMebeverine does not have an anticholinergic actionIt directly relaxes smooth musclemainly in the gastrointestinal tractThe preparation eliminates spasmwithout exerting a significant effect on the normal intestinal peristalsis.

In appointing of the preparation during pregnancy must be weighed the profit to the mother and the possible danger to the fetusWhen administered in therapeutic doses Mebeverine does not penetrate into breast milktherefore its usage during lactation is allowed.

Adultsspasms of the gastrointestinal tractincluding those which are due to organic diseasebiliary colicintestinal colicIrritable bowel syndromecuring of pain and spasms and disorders and intestinal discomfortChildren over 12 yearsfunctional disorders of the gastrointestinal tractaccompanied by abdominal pain.

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