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This medication may rarely cause serious problems from blood clotssuch as heart attacksstrokesdeep vein thrombosispulmonary embolismGet medical help right away if you have any serious side effectsincludingchest/jaw/left arm painunusual sweatingsudden/severe headacheweakness on one side of the bodyconfusionslurred speechsudden vision changessuch as partial/complete blindnesspain/redness/swelling of legstingling/weakness/numbness in the arms/legstrouble breathingcoughing up bloodsudden dizziness/fainting.

Some other studiesincluding the WHI trialsuggest that the use of combined HRTs may be associated with a similar or slightly smaller risksee section 4.8

This medication is a female hormoneIt is used by women to help reduce symptoms of menopausesuch as hot flashesvaginal drynessThese symptoms are caused by the body making less estrogenIf you are using this medication to treat symptoms only in and around the vaginaproducts applied directly inside the vagina should be considered before medications that are taken by mouthabsorbed through the skinor injected.

Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementiasee WARNINGS AND PRECAUTIONSand Clinical Studies

17Exogenous estrogens may induce or exacerbate symptoms of angioedemaparticularly in women with hereditary angioedema.

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