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No pharmacokinetic drug-drug interaction studies were conducted with Persantinedipyridamole USPTabletsThe following information was obtained from the literature.

In studies in which dipyridamole was administered in the feed to miceup to 111 weeks in males and femalesand ratsup to 128 weeks in males and up to 142 weeks in femalesthere was no evidence of drug-related carcinogenesisThe highest dose administered in these studies75 mg/kg/daywason a mg/m 2 basisabout equivalent to the maximum recommended daily human oral doseMRHDin mice and about twice the MRHD in ratsMutagenicity tests of dipyridamole with bacterial and mammalian cell systems were negativeThere was no evidence of impaired fertility when dipyridamole was administered to male and female rats at oral doses up to 500 mg/kg/dayabout 12 times the MRHD on a mg/m 2 basisA significant reduction in number of corpora lutea with consequent reduction in implantations and live fetuses washoweverobserved at 1250 mg/kgmore than 30 times the MRHD on a mg/m 2 basis

Adverse reactions at therapeutic doses are usually minimal and transientOn long-term use of Persantinedipyridamole USPtablets initial side effects usually disappearThe following reactions in Table 1 were reported in two heart valve replacement trials comparing PersantinedipyridamoleE tablets and warfarin therapy to either warfarin alone or warfarin and placebo:

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dipyridamole may counteract the anticholinesterase effect of cholinesterase inhibitors, thereby potentially aggravating myasthenia gravis.

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