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An evaluation of the effect of food on Lamisil Tablets was conductedAn increase of less than 20of the AUC of terbinafine was observed when Lamisil Tablets were administered with foodLamisil Tablets can be taken with or without food.
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Advise patients to immediately report to their physician or get emergency help if they experience any of the following symptomshivesmouth soresblistering and peeling of skinswelling of facelipstongueor throatdifficulty swallowing or breathingLamisil Tablets treatment should be discontinuedAdvise patients to immediately report to their physician any symptoms of persistent nauseaanorexiafatiguevomitingright upper abdominal painjaundicedark urineor pale stoolsLamisil Tablets treatment should be discontinuedAdvise patients to report to their physician any signs of taste disturbancesmell disturbance and/or depressive symptomsfeverskin eruptionlymph node enlargementerythemascalingloss of pigmentand unusual photosensitivity that can result in a rashLamisil Tablets treatment should be discontinuedAdvise patients to minimize exposure to natural and artificial sunlighttanning beds or UVA/B treatmentwhile using Lamisil TabletsAdvise patients that if they forget to take Lamisil Tabletsto take their tablets as soon as they rememberunless it is less than 4 hours before the next dose is dueAdvise patients to call their physician if they take too many Lamisil Tablets.
Terbinafinean allylamine antifungalinhibits biosynthesis of ergosterolan essential component of fungal cell membranevia inhibition of squalene epoxidase enzymeThis results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiencyDepending on the concentration of the drug and the fungal species test in vitroterbinafine hydrochloride may be fungicidalHoweverthe clinical significance of in vitro data is unknown.
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